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Inform people that: Tramadol Hydrochloride Extended-Release is for oral use only and should be swallowed entire. The capsule should not be chewed, dissolved, crushed or split. Tramadol Hydrochloride Extended-Release may trigger seizures and/or serotonin syndrome with concomitant utilization of serotonergic agents (such as SRIs, NRIs, and triptans)